General Spectrum of Activity
Reserved for highly resistant infections or when significant allergies restrict other options and when there is documented susceptibility.
Associated with more treatment failures than alternatives and excess mortality - Black Box Warning.
Oral contraceptives less effective.
Requires Infectious Disease consultation.
Documented safety concerns in bacteremia especially.
Antimicrobial class: Tetracycline derivative
Pregnancy category: D
Average serum half life: 42 hours
Lung penetration: Therapeutic
Biliary penetration: Therapeutic