Antimicrobials
Tigecycline

Tigecycline

Restricted

Medium
None
N*****

Spectrum of Activity

Dosing

General Information

Reserved for highly resistant infections or when significant allergies restrict other options and when there is documented susceptibility.

Associated with more treatment failures than alternatives and excess mortality - Black Box Warning.

  • Nausea
  • Vomiting
  • Allergic reactions
  • Photosensitivity
  • Pseudo tumor cerebri
  • Pancreatitis

Oral contraceptives less effective.

Requires Infectious Disease consultation.

Documented safety concerns in bacteremia especially.

Antimicrobial class: Tetracycline derivative

Pregnancy category: D

Average serum half life: 42 hours

Lung penetration: Therapeutic

Biliary penetration: Therapeutic