Antimicrobials
Fluconazole

Fluconazole

Low
Excellent
See below

Spectrum of Activity

Dosing

General Information

  • N30-N200 / 50mg cap
  • N65-N450 / 200mg cap
  • N750 / susp
  • Candida infections both mucocutaneous and invasive - i.e. Candidemia
  • Cryptococcus and Coccidioides infections
  • Antifungal prophylaxis in immunocompromised

Consider QTc monitoring if concomitant drugs affecting the interval or elevated baseline measurement.

  • Drug interactions
  • QTc prolongation
  • Hepatic enzyme abnormalities
  • Rash
  • Alopecia
  • GI upset

Many via CYP450. Suggest review specific patient medications.

Fluconazole increases levels of phenytoin, cyclosporine, tacrolimus, warfarin, oral hypoglycemics.

Risk when combining with other QTc prolonging medications.

Antimicrobial class: Triazole antifungal

Pregnancy category: C

Average serum half life: 20 hours

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic