Cholera
Ciprofloxacin

Ciprofloxacin

High
Excellent
See below

Spectrum of Activity

Dosing

General Information

  • N25-N50/500mg tab
  • N300/vial

Pseudomonal and other gram negative infections of urinary tract, bone/joint, abdomen and other sites

Monitor QTc in patients with increased risk

  • Nausea
  • Vomiting
  • Abdominal discomfort
  • Arthralgia
  • Photosensitivity
  • Transient elevation of liver enzymes
  • CYP1A2 inhibitor - Multiple interactions possible
  • QTc prolongation - Increased risk with other agents that prolong QTc
  • Divalent & trivalent cations including Al, Ca, Fe, Mg (antacids, dairy products, iron supplements, some enteral feeds) - Decreased absorption
  • Cyclosporine - Increased levels of cyclosporine
  • Warfarin - Increased INR
  • Methadone - Lowered seizure threshold

Antimicrobial class: Fluoroquinolone

Pregnancy category: C

Average serum half life: 4 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Moderate

Biliary penetration: Therapeutic