Antimicrobials
Cefepime

Cefepime

Restricted
C difficile risk
High
Oral Bioavailability
N/A
Cost
N*****

Dosing

50 mg/kg q12h for 10 days

Maximum: 4 g/day

1-4 gm/day IV in 2-3 doses

Maximum: 4 g/day

Adjust dose in renal failure

General Information

Broad spectrum antimicrobial with gram positive and gram negative coverage including Pseudomonas.

Used especially nosocomial infections involving resistant organisms

Same as third generation cephalosporins

Antimicrobial class: 4th generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Biliary penetration: Moderate

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic