Antimicrobials
Azithromycin

Azithromycin

Medium
Moderate
See below

Spectrum of Activity

Dosing

General Information

  • N65 - N350/250mg tab
  • N150 - N450/500mg tab
  • N600 - N1500/200mg susp
  • Community acquired pneumonia
  • Pertussis
  • Upper respiratory tract infections
  • Chlamidial infections
  • Mycobacterial infections
  • Mycobacterium avium complex (MAC) prophylaxis in HIV patients

Monitor QTc in patients with increased risk

  • Leukpenia
  • Transient elevation of liver enzymes
  • Renal toxicity
  • Other drugs that prolong QTc
  • Increases cyclosporine levels
  • May increase digoxin levels
  • Statins increased risk of rhabdomyolysis

Very high tissue penetration and concentration intracellularly means in vivo activity may not be predicted by in vitro testing - e.g. Salmonella species.

Antimicrobial class: Macrolide

Pregnancy category: B

Average serum half life: 68 hours

Urine penetration: Poor

Lung penetration: Therapeutic

CSF penetration: Poor

Biliary penetration: Therapeutic