Antimicrobials
Amikacin

Amikacin

Low
N/A
N********

Spectrum of Activity

Dosing

General Information

Therapy of gram negative organisms resistant to gentamicin and tobramycin but susceptible to amikacin (HAP, UTI, other).

As combination therapy for the treatment of some Mycobacteria species (e.g. M. abscessus).

  • Monitor creatinine at least 3 times/week. Discontinue if any signs of ototoxicity
  • For BID dosing:

    • Target Peak 15-30 mg/L, Trough <5 mg/L
    • Peak levels usually not required but if drawn, record time of dose and time of level draw as accurately as possible
  • Consult pharmacist for level interpretation and dose individualization

  • For once daily dosing:

    • Target Trough <1 mg/L
    • Peak levels not recommended
  • Nephrotoxicity
  • Ototoxicity

Increased nephrotoxicity with:

  • Amphotericin B
  • Cyclosporine
  • Cisplatin
  • NSAIDS
  • Contrast dye
  • Vancomycin

Increased ototoxicity with:

  • Furosemide

Respiratory paralysis with:

  • Neuromuscular blockade agents

Formal audiology assessment required if planning to use aminoglycoside for >7d or if symptoms develop.

Inform patient of risk of ototoxicity and to report any symptoms.

Antimicrobial class: Aminoglycoside

Pregnancy category: D

Average serum half life: 2.5 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Poor

Biliary penetration: Moderate