Antimicrobials
Tobramycin

Tobramycin

Low
N/A

Dosing

General Information

  • It is recommended to use Extended Interval Dosing if possible for optimal bactericidal activity, convenience, potentially reduced risk of nephrotoxicity and reduced cost for administration
  • Extended interval aminoglycoside dosing is the preferred dosing regimen but should NOT TO BE USED in the following:
    • Burns >20% TBSA (total burn surface area)
    • Ascites
    • Pregnancy
    • Renal impairment (creatinine clearance < 40 mL/min)
  • If excluded, refer to Conventional Dosing
  • Nephrotoxicity (non-oliguric)
  • Vestibulocochlear toxicity
  • Can exacerbate neuromuscular blockade - e.g. contraindicated in patients with myasthenia gravis

Avoid concurrent nephrotoxic or ototoxic drugs (e.g. furosemide) whenever possible.

Antimicrobial class: Aminoglycoside

Pregnancy category: D