Antimicrobials
Linezolid

Linezolid

Restricted

Low
Excellent

Dosing

General Information

Restricted to infections caused by gram positive organisms that are resistant to vancomycin or in patients intolerant to vancomycin.

  • CBC at least once/week
  • Visual testing for therapy >3 mo or if symptoms develop on therapy
  • Myelosuppression (usually after 2 weeks therapy) - reversible
  • Peripheral/optic neuropathy with prolonged courses
  • Serotonin syndrome
  • Rash
  • Elevated liver enzymes
  • Lactic acidosis
  • SSRI and other serotonergics/MAOIs - increased risk of serotonin syndrome
  • Rifampin decreases linezolid levels

Antimicrobial class: Oxazolidinone

Pregnancy category: C