Antimicrobials
Cotrimoxazole (Sulfamethaxole+Trimethoprim)

Cotrimoxazole (Sulfamethaxole+Trimethoprim)

Low
Excellent

Dosing

General Information

  • Urinary tract infections
  • Susceptible MRSA infections
  • Stenotrophomonas infections
  • Pneumocystis jirovecii pneumonia (Treatment or prophylaxis)

Follow creatinine and electrolytes in patients at increased risk renal failure, hyperkalemia.

  • Gastrointestinal upset common

  • Bone marrow suppression

  • Hyperkalemia

  • Renal failure

  • Hepatitis

  • Aseptic meningitis

  • Stevens Johnson syndrome/toxic epidermal necrolysis

  • Other rashes

  • ACEi - Increased serum potassium level

  • Increases amantadine levels

  • Decreases cyclosporine

  • Methotrexate - Marrow suppression

  • Increases phenytoin

  • Increases rifampin

  • Increases INR with warfarin

Antimicrobial class: Sulfonamide - Antifolate

Pregnancy category: C

Average serum half life: 10 hours

Biliary penetration: Moderate

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic