E. coli, Klebsiella, Proteus
Bacteroides sp., Fusobacterium sp.
Enterococcal coverage only generally necessary if:
First line
OR
First line
AND
First line
OR
Second line
AND
Second line
First line
AND
First line
OR
Second line
AND
Second line
5 days minimum
Longer duration of therapy is not associated with improved outcome
On Day 3 or when cultures and sensitivities results are available, tailor antimicrobial therapy to pathogen
Consider diagnostic investigation, if experiencing inadequate clinical response at Day 4-7