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Antimicrobials
Trimethoprim-Sulfamethoxazole

Trimethoprim-Sulfamethoxazole

Low
Good (70 to 90%)
PO: 0.23$/day IV: 71.51$/day

Dosing

General Information

  • Urinary tract infections
  • Susceptible MRSA infections
  • Stenotrophomonas infections
  • Pneumocystis jirovecii pneumonia (treatment or prophylaxis)

Monitor:

  • Renal function: creatinine
  • Potassium and electrolytes
  • Gastrointestinal upset common
  • Bone marrow suppression
  • Hyperkalemia
  • Renal failure
  • Hepatitis
  • Aseptic meningitis
  • Stevens Johnson syndrome/toxic epidermal necrolysis
  • Other rashes
  • ACEi and spironolactone- Increased serum potassium level
  • Increases amantadine levels
  • Decreases cyclosporine
  • Methotrexate - Marrow suppression
  • Increases phenytoin
  • Increases rifampin
  • Increases INR with warfarin

Antimicrobial class: Sulfonamide - Antifolate

Pregnancy category: C

Average serum half life: 10 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Therapeutic

Biliary penetration: Moderate