Piperacillin-Tazobactam
Renal

Renal

In the setting of rapidly improving/worsening renal function, calculations of eGFR are inaccurate, and dosing should be based on estimated renal function instead.

If worsening renal function, actual GFR is likely lower than calculated.

If improving renal function, actual GFR is likely higher than calculated eGFR.

Non-Pseudomonal coverage

CrCl > 40

3.375g IV q6h

CrCl 20-40

2.25g IV q6h

CrCl <20

2.25g IV q8h

Pseudomonal coverage or Severe infection

CrCl >40

4.5g IV q6h

CrCl 20-40

3.375g IV q6h

CrCl <20

2.25g IV q6h