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Antimicrobials
Piperacillin-Tazobactam

Piperacillin-Tazobactam

Medium
N/A

Dosing

General Information

Broad spectrum agent with anti-pseudomonal activity.

Used for severe infections including:

  • Pneumonia
  • Intra-abdominal/hepatobiliary
  • UTI
  • Polymicrobial skin and soft tissue infection
  • Febrile neutropenia

Monitor:

  • Renal function: creatinine, BUN
  • LFTs
  • Allergy/rash (immediate or delayed)
  • Cytopenias- esp. thrombocytopenia
  • Eosinophilia
  • Interstitial nephritis
  • Abnormal liver enzymes

Vancomycin and Piperacillin-Tazobactam (Tazocin) concomitant administration may lead to synergistic nephrotoxicity.

Incr. levels of methotrexate.

Antimicrobial class: Ureidopenicillin with a beta-lactamase inhibitor

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Therapeutic