Antimicrobials
Cloxacillin

Cloxacillin

C difficile risk
Medium
Oral Bioavailability
N/A

Dosing

Osteomyelitis, Pneumonia, SSTIEndocarditis2g IV q6h2g IV q4h

General Information

Treatment of MSSA infections

  • Allergy (immediate or delayed)

  • Cytopenias

  • Eosinophilia

  • Interstitial nephritis

  • Abnormal liver enzymes

  • Phlebitis at injection site in a peripheral vein

Can increase methotrexate levels.

Decrease mycophenolate levels.

Tetracyclines can diminish cloxacillin activity.

Antimicrobial class: Antistaphylococcal Penicillin

Pregnancy category: B

Average serum half life: 1 hour

Urine penetration: Therapeutic

Lung penetration: Therapeutic

Biliary penetration: Moderate