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Antimicrobials
Ceftriaxone

Ceftriaxone

C difficile risk
High
Oral Bioavailability
N/A

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Adult

Usual DosingBacterial MeningitisChlamydia/Gonococcal Infection (usually treated together)1-2gm IV q24h 2gm IV q12h250mg ceftriaxone IM + 1g azithromycin PO

General Information

Common Usage

Empiric therapy of:

  • Community acquired pneumonia

  • Bacterial meningitis

  • Pyelonephritis

  • Nosocomial gram negative infections (except Pseudomonas)

  • Spontaneous bacterial peritonitis

  • Hospitalized community or nursing home acquired pneumonia in combination with a macrolide

Adverse Effects

  • Allergy/rash (immediate or delayed)

  • Cytopenias

  • Eosinophilia

  • Hepatic & renal laboratory abnormalities

  • Pseudocholelithiasis

    • Unclear clinical significance
    • Uncommonly symptomatic, but frequently by ultrasound gallbladder sludge

Major Interactions

Do not co-administer with calcium-containing solutions (including Ringer's lactate)

Additional Information

Contraindicated in neonates (Age 0-28 days)

Pharmacology

Antimicrobial class: Parenteral Cephalosporin - 3rd Generation

Pregnancy category: B

Average serum half life: 8 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Therapeutic

Biliary penetration: Therapeutic