Cefotaxime
General Spectrum of Activity

General Spectrum of Activity

Very similar to ceftriaxone

Gram positive

  • Group A,B,C,G Streptococci
  • S. pneumoniae
  • Viridans Streptococci

Gram negative

  • Most Enterobacteriaceae
  • H. influenzae
  • M catarrhalis
  • Pasteurella species

Anaerobes

  • Prevotella melaninogenica
  • Clostridium (not C. difficile)
  • Peptostreptococci

Does not cover

  • Enterococci
  • B. fragilis
  • Pseudomonas and other more resistant gram negatives
  • ESBL or AmpC producing Enterobacteriaceae
  • Listeria
  • Not the agent of choice for Staphylococcal infections