In the setting of rapidly improving/worsening renal function, calculations of eGFR are inaccurate, and dosing should be based on estimated renal function instead.
If worsening renal function, actual GFR is likely lower than calculated.
If improving renal function, actual GFR is likely higher than calculated eGFR.
Not On Dialysis
2g IV q24h
2g IV q12h-24h
2g IV q8-12h
Intermittent Dialysis
1-2g IV q24h
Dosed after HD on dialysis days
Continuous Dialysis
2g IV q12h
