Cefotaxime
Renal

Renal

In the setting of rapidly improving/worsening renal function, calculations of eGFR are inaccurate, and dosing should be based on estimated renal function instead.

If worsening renal function, actual GFR is likely lower than calculated.

If improving renal function, actual GFR is likely higher than calculated eGFR.

Not On Dialysis

eGFR 0 - 10

2g IV q24h

eGFR 10 - 50

2g IV q12h-24h

eGFR > 50

2g IV q8-12h

Intermittent Dialysis

1-2g IV q24h

Dosed after HD on dialysis days

Continuous Dialysis

2g IV q12h