Antimicrobials
Caspofungin

Caspofungin

Low
N/A

Spectrum of Activity

Dosing

General Information

Caspofungin is often used in management of suspected and confirmed invasive fungal infections, particularly Candidiasis and Aspergillosis

Liver enzymes at baseline and every 1-2 weeks

  • Infusion-related reactions (rash, pruritis)
  • Phlebitis
  • Headache
  • Nausea and vomiting
  • Elevations in hepatic enzymes

As per TOH Parenteral Manual, if patient receives concomitant inducers of drug clearance, may consider giving 70mg IV daily.

Inducers:

  • Efavirenz
  • Nevirapine
  • Rifampin
  • Dexamethasone
  • Phenytoin
  • Carbamazepine

Caspofungin has poor vitreous, CNS and urinary penetration. It should not be used for treatment of Candida urinary tract infections

Antimicrobial class: Echinocandin

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Poor