500mg PO/IV on day 1 then 250mg daily for 4 days
1g as single dose with 250mg ceftriaxone IM
Community acquired pneumonia
Upper respiratory tract infections
Mycobacterium avium complex (MAC) prophylaxis in HIV patients
Monitor QTc in patients with increased risk
Prolongation of QTc interval. Association with increased cardiovascular mortality in observational studies.
Prolonged half life may contribute to macrolide resistance.
Other drugs that prolong QTc
Increases cyclosporine levels
May increase digoxin levels
Statins increased risk of rhabdomyolysis
Bioavailability: 37% - low
The low bioavailability is compensated with very high tissue penetration.
Very high tissue penetration and concentration intracellularly means in vivo activity may not be predicted by in vitro testing - e.g. Salmonella species.
Antimicrobial class: Macrolide
Pregnancy category: B
Average serum half life: 68 hours
Urine penetration: Poor
Lung penetration: Therapeutic
CSF penetration: Poor
Biliary penetration: Therapeutic