Deep infection - Inpatient


If osteomyelitis is suspected, consider holding empiric antibiotic therapy until adequate specimens are obtained for culture if patient is not septic and/or has no evidence of serious soft tissue infection. Consider discussing with ID.

Wound Not Contaminated

Antipseudomonal Therapy

Consider pseudomonas coverage for the following risk factors:

  • puncture through sole of a shoe

  • wound is contaminated with soil

  • patient is severely septic

  • history of pseudomonas skin infection



MRSA Coverage

Consider MRSA coverage for the following risk factors:

  • MRSA colonization/previous skin infection

  • IVDU

  • Wound with purulent drainage

  • Recent and/or frequent broad spectrum antibiotic exposure

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