AmpC Organisms

Precautions

Contact Precautions
Contact Precautions

General Information

Gram negative organisms, usually "SPICEM" (Serratia, Pseudomonas, Providencia, Citrobacter, Enterobacter, Morganella), that have a chromosomal beta-lactamase.

Most AmpC organisms are nosocomially encountered, are GI flora and are part of the Enterobacteriaceae family.

Syndromes caused by the organism that possesses AmpC (see individual organism).

  • AmpC organisms are difficult to identify using susceptibility reports alone. A pathogen may harbor AmpC and/or ESBL enzymes if it appears resistant to multiple beta lactams.

  • In the lab, AmpCs test resistant to cefoxitin and cefotetan, whereas ESBLs remain susceptible to these.

  • ESBLs vs. AmpC: Most ESBLs are plasmid-encoded, whereas AmpCs are usually inducible and chromosomal.

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