AmpC Organisms

General Susceptibility

  • Intrinsic resistance to ampicillin and lower generation cephalosporins.

  • Usually susceptible to fluoroquinolones, TMP-SMX, and aminoglycosides which are appropriate targeted therapy options.

  • Susceptible to carbapenems.

  • With exposure to beta-lactams, induction or de-repression can occur and confer resistance to third generation cephalosporins.

  • Using Pip-Tazo and Ceftriaxone when reported as susceptible is likely reasonable for simple infections requiring short duration.

  • Cefepime when reported as susceptible is reasonable for most infections.

  • Life-threatening and Bloodstream infections should be managed with a carbapenem.

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