Neisseria meningitidis


Droplet Precautions

General Information

Encapsulated gram negative diplococci.

Normal flora. Humans are the reservoir.

Quadrivalent vaccine prevents disease by serogroups A/C/W-135/Y.

Occurs in outbreaks particularly in crowded settings.

Colonizer and cause of invasive disease:

  • Meningitis

  • Meningococcemia


  • Pneumonia

  • Septic arthritis

  • Pericarditis

  • Conjunctivitis

  • Others

Generally of little significance when cultured from nonsterile sites e.g. genital, pharynx.

Prophylaxis is indicated for:

  • Any household, child care or intimate contact

  • Medical personnel with contact w/ oral secretions within 7d on symptom onset

  • Travelers with exposure to respiratory secretions from index patient

  • Exposure to oral secretions = kissing, mouth-to-mouth resuscitation, person performing endotracheal intubation or managing an ET tube

Prophylactic Regimens (Patients 15 yo+)

  • Ciprofloxacin 500 mg PO once

  • Rifampin 600 mg PO q12h x 2 days

  • Ceftriaxone 250 mg IM once

Prophylactic Regimens (Peds < 15 yo)

  • <1 month: Rifampin 5 mg/kg q12h PO x 2 days

  • ≥ month: Rifampin 10 mg/kg q12h PO x 2 days

  • Less than 15 y.o: Ceftriaxone 125 mg IM x 1

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