In the setting of rapidly improving or worsening renal function, calculations of CrCl are inaccurate. Dosing should be based on estimated renal function instead.
If improving renal function, actual CrCl is likely higher than calculated CrCl.
If worsening renal function, actual CrCl is likely lower than calculated CrCl.
Not On Dialysis
500mg PO q24h
500mg PO q12h
500mg PO q12h
Intermittent Dialysis
500mg PO q24h
Dose after dialysis on HD days