Cefuroxime - Renal Dosing

In the setting of rapidly improving or worsening renal function, calculations of CrCl are inaccurate. Dosing should be based on estimated renal function instead.

If improving renal function, actual CrCl is likely higher than calculated CrCl.

If worsening renal function, actual CrCl is likely lower than calculated CrCl.

CrCl <10

PO

  • PNA/SSTI: 500 mg q48h

  • UTI, mild SSTI: 250 mg PO q48h

IV

  • 1.5 gm IV q24h

CrCl 10 - 29

PO

  • PNA/SSTI: 500 mg q24h

  • UTI, mild SSTI: 250 mg PO q24h

IV

  • 1.5 gm IV q12h

CrCl > 30

Usual dosing

PO

  • 250-500 mg q48 + a supplemental dose after each HD session

IV

  • 1.5 gm q24 + a supplemental dose after each HD session
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