C difficile risk
Oral Bioavailability


Severe infection: 2 g q8h; Mild infection: 1g q8h

CrCl 0 - 10CrCl 10 - 29CrCl 30 - 50CrCl > 501-2g IV q24h1 g q24 - 2 g q12h (severe infection)1 g q12h - 2 g q8h (severe infection)Usual adult dose

  • 1g IV daily given post-HD on dialysis days.

  • For serious infections consider 2g IV daily.

Other regimens exist.

1-2g IV q12h

General Information

Skin and soft tissue infection (e.g. cellulitis).

Surgical prophylaxis.

Susceptible Staphylococcal, Streptococcal and gram negative infections.

Allergy (immediate or delayed).

Can cause positive Coombs, cytopenias, and hepatic and renal laboratory abnormalities.

Probenecid - prolonged half-life.

Antimicrobial class: 1st Generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Therapeutic

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