Ampicillin

C difficile risk
Low
Oral Bioavailability
N/A

Dosing

  • Meningitis or endocarditis: 2g IV q4h

  • Pyelonephritis: 2g IV q6h

  • Uncomplicated UTI: 1 g IV q6h

CrCl > 50CrCl 0 - 10CrCl 10 - 29CrCl 30 - 50Usual adult dose- Meningitis or endocarditis: 2g IV q12h

  • Pyelonephritis: 2g IV q24h

  • Uncomplicated UTI: 1 g IV q24h- Meningitis or endocarditis: 2g IV q8h

  • Pyelonephritis: 2g IV q12h

  • Uncomplicated UTI: 1 g IV q12h- Meningitis or endocarditis: 2g IV q6h

  • Pyelonephritis: 2g IV q8h

  • Uncomplicated UTI: 1 g IV q8h

  • Meningitis or endocarditis: 2g IV q12h

  • Pyelonephritis: 2g IV q24h

  • Uncomplicated UTI: 1 g IV q24h

Give doses after HD on HD days, if possible

Load 2g then 1-2g IV q6h

General Information

Pathogen directed therapy for CNS, intravascular, intraabdominal, urinary and other infections especially Enterococcus and Listeria.

Allergy and rash

Note: rash may occur when used in setting of EBV/infectious mononucleosis - not a true allergy

Rare: cytopenias, + Coombs.

Increased risk of rash with allopurinol.

Antimicrobial class: Aminopenicillin

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic

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