Aztreonam

C difficile risk
Medium
Oral Bioavailability
N/A
Cost
High

Dosing

2g IV q8h for severe infections

CrCl 0 - 10CrCl 10 - 50CrCl > 50Severe infx: 2 g Load, then 500 mg q6-8hSevere infx: 2 g load, then 1 - 1.5g q6-8hUsual adult dose

2 g load, then 500 mg IV q6-8h + 125 mg after dialysis

2g IV load then 1g IV q6h

General Information

Therapy of gram negative infections including Pseudomonas, particularly in patients with penicillin and cephalosporin allergy or when there is no alternative susceptible agent.

Nebulized form used in cystic fibrosis patients.

Empiric therapy for febrile neutropenia.

Monitor liver enzymes

  •  Elevated liver enzymes

  •  Cytopenias

  •  Eosinophilia

  •  Phlebitis at injection site

  •  Rash/allergy

  •  CNS toxicity

No significant interactions.

Patients allergic to ceftazidime can have cross-allergy due to shared side chain.

Antimicrobial class: Monobactam

Pregnancy category: B

Average serum half life: 2 hours

Biliary penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic

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