875 mg PO BID or 500 mg PO TID
2 gm ER formulation PO BID
CrCl 0 - 10CrCl 10 - 50CrCl > 50250-500mg PO q24h250-500mg PO q12h500mg PO q8h
250-500mg PO q24h
Prophylaxis/treatment of bite wounds.
Polymicrobial infections of the respiratory tract or abdomen.
Skin and soft tissue infections.
For prolonged therapy, monitor liver enzymes and function.
Allergy/rash (immediate or delayed)
Note rash common when used in setting of EBV/infectious mononucleosis - not a true allergy
Hepatotoxicity due to clavulanate - usually mild, liver failure is rare.
Increased risk of rash with allopurinol
Antimicrobial class: Aminopenicillin + Beta-lactamase inhibitor
Pregnancy category: B
Average serum half life: 1 hour
Biliary penetration: Therapeutic
Lung penetration: Therapeutic
Urine penetration: Therapeutic