Amoxicillin-Clavulanate

C difficile risk
Medium
Oral Bioavailability
Excellent

Dosing

875 mg PO BID or 500 mg PO TID

2 gm ER formulation PO BID

CrCl 0 - 10CrCl 10 - 50CrCl > 50250-500mg PO q24h250-500mg PO q12h500mg PO q8h

250-500mg PO q24h

General Information

Prophylaxis/treatment of bite wounds.

Polymicrobial infections of the respiratory tract or abdomen.

Skin and soft tissue infections.

For prolonged therapy, monitor liver enzymes and function.

  • Diarrhea

  • Allergy/rash (immediate or delayed)

  • Note rash common when used in setting of EBV/infectious mononucleosis - not a true allergy

  • Cytopenias

  • Hepatotoxicity due to clavulanate - usually mild, liver failure is rare.

Increased risk of rash with allopurinol

Antimicrobial class: Aminopenicillin + Beta-lactamase inhibitor

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic

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