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Antimicrobials
Amoxicillin-Clavulanate

Amoxicillin-Clavulanate

Medium
Excellent

Dosing

General Information

Prophylaxis/treatment of bite wounds.

Polymicrobial infections of the respiratory tract or abdomen.

Skin and soft tissue infections.

For prolonged therapy, monitor liver enzymes and function.

  • Diarrhea
  • Allergy/rash (immediate or delayed)
  • Note rash common when used in setting of EBV/infectious mononucleosis - not a true allergy
  • Cytopenias
  • Hepatotoxicity due to clavulanate - usually mild, liver failure is rare.

Increased risk of rash with allopurinol

Antimicrobial class: Aminopenicillin + Beta-lactamase inhibitor

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic