Vancomycin IV

C difficile risk
None
Oral Bioavailability
N/A

Dosing

  • 25-30mg/kg IV loading dose (for severe infections or if morbidly obese)

  • 10-15mg/kg IV q6-24h maintenance depending on trough goal and renal fuction

CrCl 0 - 50 Dose per pharmacy

Dose per pharmacy

Dose per pharmacy

General Information

Suspected or proven MRSA, coagulase-negative Staphylococcal infections, Enterococcal infections.

Collect trough 0-1h before 3rd dose if abnormal/fluctuating renal function.

Target trough 15-20mcg/mL for most serious infections, 20-25mcg/mL for meningitis

  •  Nephrotoxicity

  •  Cytopenias

  •  Rash including Stevens-Johnson Syndrome

  •  Red man syndrome (histamine release- slow down infusion)

Aminoglycosides may potentiate nephrotoxicity.

May enhance neuromuscular blockade of NM blocking agents.

Careful with concomitant nephrotoxins.

Antimicrobial class: Glycopeptide

Pregnancy category: C

Average serum half life: 8 hours

Biliary penetration: Moderate

CSF penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic

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