General Spectrum of Activity
Candida infections both mucocutaneous and invasive - i.e. Candidemia.
Antifungal prophylaxis in immunocompromised patients.
Therapeutic drug monitoring may be helpful to ensure adequate concentrations and exclude toxicity (Discuss with ID).
QTc interval in patients at elevated risk.
Monitor hepatic profile.
Many significant drug interactions, including CYP450 interactions. Medications should be reviewed carefully before voriconazole is used.
Antimicrobial class: Triazole antifungal, Second generation
Pregnancy category: D
CSF penetration: Therapeutic
Lung penetration: Therapeutic
Urine penetration: Poor