Meropenem - Renal Dosing

In the setting of rapidly improving or worsening renal function, calculations of CrCl are inaccurate. Dosing should be based on estimated renal function instead.

If improving renal function, actual CrCl is likely higher than calculated CrCl.

If worsening renal function, actual CrCl is likely lower than calculated CrCl.

CrCl 0 - 10

  • Standard Dose: 500mg IV q24h (over 3-hr or 30-min)

  • Meningitis: 1g IV q24h (over 3-hr or 30-min)

CrCl 10 - 29

  • Standard Dose: 500mg IV q12h (over 3-hr or 30-min)

  • Meningitis: 1g IV q12h (over 3-hr or 30-min)

CrCl 30 - 50

  • Standard Dose: 500mg IV q8h (over 3-hr) -or- 500 mg q8h - 1g IV q12h (over 30-min)

  • Meningitis: 2g IV q12h (over 3-hr or 30-min)

CrCl > 50

Usual dosing

  • Standard Dose: 500mg IV q24h (over 3-hr or 30-min)

  • Meningitis: 1g IV q24h (over 3-hr or 30-min)

500 mg - 1 g IV q8h (over 3-hr or 30-min)

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