Spectrum Of Activity
600mg PO/IV q12h
Targeted or empiric therapy for gram positive infections including skin and soft tissue, and pneumonia.
Bacteriostatic, do not use 1st line for suspected/confirmed invasive bloodstream infections.
Covers MRSA and VRE.
CBC at least once/week
Visual testing for therapy >3 months or if symptoms develop on therapy.
Elevated liver enzymes
Myelosuppression esp. thrombocytopenia (usually with >2weeks therapy)- reversible
Serotonin syndrome (in combination w/ other serotonergic agents)
Peripheral/optic neuropathy with prolonged courses
SSRI and other serotonergics/MAOIs - Increased risk of serotonin syndrome.
Rifampin decreases linezolid levels.
Antimicrobial class: Oxazolidinone
Pregnancy category: C
Average serum half life: 5 hours
CSF penetration: Therapeutic
Lung penetration: Therapeutic
Urine penetration: Therapeutic