Moxifloxacin

Restricted
C difficile risk
High
Oral Bioavailability
Excellent
Cost
Non-formulary for inpatient use at MHS

Dosing

400mg IV/PO daily

General Information

Pneumonia including CAP, HAP, aspiration

Some intra-abdominal infections

CNS infections

Monitor QTc in patients with increased risk

  • QTc prolongation

  • Dysglycemia

  • Rash

  • Tendinopathy and rupture

  • GI upset

  • Weakness exacerbation in myasthenia gravis

  • CNS toxicity including confusion, psychosis

QTc prolongation - Increased risk with other agents that prolong QTc

Divalent cations including Ca, Mg - Decreased absorption

Warfarin - Increased INR

Rifampin - Decrease moxifloxacin levels

Antimicrobial class: Fluoroquinolone

Pregnancy category: C

Average serum half life: 12 hours

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Poor

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