Spectrum Of Activity
Inpatient: 500mg PO/IV x 3 days
Outpatient: 500 mg PO x 3 days, or, 500mg PO on day 1 then 250mg daily for 4 days
Community acquired pneumonia
Upper respiratory tract infections
Mycobacterium avium complex (MAC) prophylaxis in HIV patients
Monitor QTc in patients with increased risk
Prolongation of QTc interval. Association with increased cardiovascular mortality in observational studies.
Prolonged half life may contribute to macrolide resistance.
Other drugs that prolong QTc
Increases cyclosporine levels
May increase digoxin levels
Potential increased risk of rhabdomyolysis when used with statins
Very high tissue penetration and concentration intracellularly means in vivo activity may not be predicted by in vitro testing.
Antimicrobial class: Macrolide
Pregnancy category: B
Average serum half life: 68 hours
Biliary penetration: Therapeutic
CSF penetration: Poor
Lung penetration: Therapeutic
Urine penetration: Poor