Oseltamivir

C difficile risk
None
Oral Bioavailability
Excellent

Dosing

15 kg or less16 to 23 kg24 to 40 kgGreater than 40 kg30 mg PO BID x 5 days45 mg PO BID x 5 days60 mg PO BID x 5 days75 mg PO BID x 5 days

Age < 3 monthsAge 3-months to 1-yearAge > 1 year AND 15 kg or less16 to 23 kg24 to 40 kgGreater than 40 kgNot recommended unless situation judged critical3 mg/kg PO Daily x 7 days30 mg PO Daily x 7-10 days45 mg PO Daily x 7-10 days60 mg PO Daily x 7-10 days75 mg PO Daily for 7-10 days

  • Treatment: 75mg PO BID x 5 days

  • Prophylaxis: 75mg PO daily x 7 days after last exposure. If severely immunocompromised or living in a SNF, seek ID input on duration of prophylaxis.

CrCl 0 - 10CrCl 10 - 30CrCl 30 - 6030 mg PO q48h30 mg PO q24h30 mg PO q12h

30mg PO load then 30mg PO after each HD session for 5 day period

75mg PO q24h

General Information

Treatment and prophylaxis of influenza

  • GI upset common

  • Rare - Stevens Johnson

  • Neuropsychiatric side effects reported

No significant interactions

Higher doses (150mg PO BID) have not been shown to be superior and are not routinely recommended

Antimicrobial class: Antiviral - Neuraminidase inhibitor

Pregnancy category: C

Average serum half life: 2 hours

Lung penetration: Therapeutic

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