Nitrofurantoin

C difficile risk
Low
Oral Bioavailability
Excellent

Dosing

Cystitis Macrobid 100mg PO BID

eGFR 0 - 30eGFR > 30Not recommendedUsual dose

Contraindicated

Contraindicated

General Information

Uncomplicated cystitis in females ONLY. Do not use for urinary infections with systemic symptoms, or when CrCL is LESS THAN 30 ml/min. Do NOT use for most males with UTI; may have some role in male CAUTI.

Interstitial pneumonitis and fibrosis especially with prolonged use.

Peripheral neuropathy.

Antacids decrease absorption

Think of this drug as a urinary antiseptic. Dosing varies based on formulation choice. Careful with product selection.

Antimicrobial class: Nitrofuran

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: None

CSF penetration: None

Lung penetration: None

Urine penetration: Therapeutic

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