Levofloxacin
Renal

Renal

In the setting of rapidly improving or worsening renal function, calculations of CrCl are inaccurate. Dosing should be based on estimated renal function instead.

If improving renal function, actual CrCl is likely higher than calculated CrCl.

If worsening renal function, actual CrCl is likely lower than calculated CrCl.

Not On Dialysis

CrCl 0 - 20
  • PNA, Pyelo, IA: 750 mg LD, then 500 mg q48h IV/PO

  • Bronchitis, Prostatitis: 500 mg LD, then 250 mg q48h IV/PO

  • Cystitis: 250 mg q48h IV/PO

CrCl 20 - 50
  • PNA, Pyelo, IA: 750 mg q48 Iv/PO

  • Bronchitis, Prostatitis: 500 mg LD, then 250 mg q24h IV/PO

  • Cystitis: 250 mg q24h IV/PO

CrCl > 50

Usual dosing

Intermittent Dialysis

500-750 mg LD, then 250 mg - 500 mg q48h IV/PO

Continuous Dialysis

500-750 mg LD, 250 - 750 mg q24h IV/PO