In the setting of rapidly improving or worsening renal function, calculations of CrCl are inaccurate. Dosing should be based on estimated renal function instead.
If improving renal function, actual CrCl is likely higher than calculated CrCl.
If worsening renal function, actual CrCl is likely lower than calculated CrCl.
Not On Dialysis
PNA, Pyelo, IA: 750 mg LD, then 500 mg q48h IV/PO
Bronchitis, Prostatitis: 500 mg LD, then 250 mg q48h IV/PO
Cystitis: 250 mg q48h IV/PO
PNA, Pyelo, IA: 750 mg q48 Iv/PO
Bronchitis, Prostatitis: 500 mg LD, then 250 mg q24h IV/PO
Cystitis: 250 mg q24h IV/PO
Usual dosing
Intermittent Dialysis
500-750 mg LD, then 250 mg - 500 mg q48h IV/PO
Continuous Dialysis
500-750 mg LD, 250 - 750 mg q24h IV/PO