General Information

  • Respiratory infections (CAP, AECOPD) for which there are no reasonable alternatives due to susceptibilities and/or life-threatening PCN allergy

Monitor QTc in patients with increased risk

  • GI upset
  • Black Box: Tendinopathy and rupture. Potentially permanent and disabling damage to tendons, muscles, joints, and nervous system including peripheral neuropathies.
  • C difficile infection
  • CNS toxicity including fatigue, confusion, memory impairment, delirium, psychosis
  • Cardiac: QTc prolongation and risk for aortic aneurysm and dissection
  • Severe blood glucose disturbances, including hypoglycemic coma
  • Weakness exacerbation in myasthenia gravis

Warfarin - Increased INR Divalent & trivalent cations including Al, Ca, Fe, Mg (antacids, dairy products, iron supplements, some enteral feeds) - Decreased absorption Oral antidiabetic agents – increased risk of hyper and hypoglycemia, including hypoglycemic coma QTc prolongation - Increased risk with other agents that prolong QTc

Antimicrobial class: Fluoroquinolone

Pregnancy category: C

Average serum half life: 7 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

Biliary penetration: Therapeutic