In the setting of rapidly improving or worsening renal function, calculations of CrCl are inaccurate. Dosing should be based on estimated renal function instead.
If improving renal function, actual CrCl is likely higher than calculated CrCl.
If worsening renal function, actual CrCl is likely lower than calculated CrCl.
Not On Dialysis
250 - 500 mg PO q12-24h
250 - 500 mg PO q8-12h
500 - 1000 mg PO q8-6h
Intermittent Dialysis
250 - 500 mg PO q24h
Dose after dialysis on hemodialysis days
