Spectrum Of Activity
Pneumonia & other severe infections: 2 gm q8 hours
Mild-moderate infections: 1 gm q8 hours
CrCl 0 - 14CrCl 15 - 30CrCl 30 - 50CrCl > 50
Severe infections: 2 gm q48 h
Mild-moderate infections: 1 gm q48 h
Severe infections: 2 gm q24 h
Mild-moderate infections: 1 gm q24 h
Severe infections: 2 gm q12 h
Mild-moderate infections: 1 gm q12 hSame as usual adult dosing
Severe infections: 1 gm q24 h
Mild-moderate infections: 500 mg q12 h
Dose after HD on dialysis days
Varies based on type of CRRT used
Broad gram negative coverage including Pseudomonas, generally used for nosocomial infections including post-neurosurgical meningitis, or other infections based on susceptibilities.
Notable lack of gram positive activity versus other cephalosporins.
Often used for nosocomial infections where psuedomonas aeruginosa is a consideration
Allergy (immediate and delayed).
Note potential cross-reactivity with aztreonam based on side chain.
Concurrent use of CEFTAZIDIME and WARFARIN may result in an increased risk of bleeding
Antimicrobial class: 3rd generation Cephalosporin
Pregnancy category: B
Average serum half life: 1-2 hours (prolonged in renal impairment)
Biliary penetration: Moderate
CSF penetration: Therapeutic
Lung penetration: Therapeutic
Urine penetration: Therapeutic
Route of Elimination: Urine (80% to 90% as unchanged drug)