Febrile Neutropenia
Piperacillin-Tazobactam

Piperacillin-Tazobactam

Medium
N/A

Dosing

General Information

Broad spectrum agent with anti-pseudomonal activity.

Used for severe infections including:

  •  Pneumonia
  •  Intra-abdominal/hepatobiliary
  •  UTI
  •  Polymicrobial skin and soft tissue infection
  •  Febrile neutropenia
  • Allergy/rash (immediate or delayed)
  • Cytopenias- esp. thrombocytopenia
  • Eosinophilia
  • Interstitial nephritis
  • Abnormal liver enzymes

May increase levels of methotrexate Increased risk of nephrotoxicity via synergism with vancomycin

Antimicrobial class: Ureidopenicillin with a beta-lactamase inhibitor

Pregnancy category: B

Average serum half life: 1 hour

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Poor

Biliary penetration: Therapeutic