Cefepime
Renal

Renal

In the setting of rapidly improving or worsening renal function, calculations of CrCl are inaccurate. Dosing should be based on estimated renal function instead.

If improving renal function, actual CrCl is likely higher than calculated CrCl.

If worsening renal function, actual CrCl is likely lower than calculated CrCl.

Not On Dialysis

CrCl 0 - 10
  • Severe infection: 1 g q24h
  • Mild-moderate infection: 500 mg q24h
  • Cystitis: 500 mg q24h
CrCl 10 - 30
  • Severe infection: 2 g q24h
  • Mild-moderate infection: 1 g q24h
  • Cystitis: 1 g q24h
CrCl 30 - 60
  • Severe infection: 2 g q 12h
  • Mild-moderate infection: 2g q24h
  • Cystitis: 1 g q24h
CrCl > 60

Usual adult dose

Intermittent Dialysis

1 g IV q24h

Dose post-HD on dialysis days

Continuous Dialysis

1 g IV 8h or 2 g IV q12h depending on type of dialysis