Penicillin G

C difficile risk
Low
Oral Bioavailability
N/A

Dosing

  • Meningitis, endovascular: 3-4 million units q4h

  • Uncomplicated infection: 2-3 million units q4-6h

CrCl 0 - 10CrCl 10 - 50CrCl > 50- Meningitis, endovascular: 75% normal dose q6h

  • Uncomplicated infection: 75% normal dose q6-8h- Meningitis, endovascular: 75% normal dose q4h

  • Uncomplicated infection: 75% normal dose q4-6hUsual dosing

  • Meningitis, endovascular: 75% normal dose q6h

  • Uncomplicated infection: 75% normal dose q6-8h

2 million units IV q4h

General Information

Therapy of Streptococcal and other documented susceptible infections.

  • Allergy/rash (immediate or delayed)

  • Seizures

  • Cytopenias

  • Eosinophilia

  • Interstitial nephritis

  • Abnormal liver enzymes

  • Serum sickness

Antimicrobial class: Penicillin

Pregnancy category: B

Average serum half life: 1 hour

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Moderate

Biliary penetration: Therapeutic

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