Ciprofloxacin
Renal

Renal

In the setting of rapidly improving or worsening renal function, calculations of CrCl are inaccurate. Dosing should be based on estimated renal function instead.

If improving renal function, actual CrCl is likely higher than calculated CrCl.

If worsening renal function, actual CrCl is likely lower than calculated CrCl.

Not On Dialysis

CrCl <30
  • 400mg IV q24h

  • 500mg PO q24h

CrCl 50-30
  • PNA/Bone-Joint/Febrile Neutropenia: 400 mg IV q12h, 500-750 mg PO q24h

  • Pyelo/Severe UTI, IA: 400 mg IV q24h, 500 mg PO q24h

  • Cystitis: 200 mg IV q24h, 250 mg PO q24h

CrCl > 50

Usual adult dose

Intermittent Dialysis

400mg IV or 500mg PO q24h

Dose after HD on dialysis days

Continuous Dialysis

400mg IV q12h