General Information

Pseudomonal and other gram negative infections of urinary tract, bone/joint, abdomen and other sites

Monitor QTc in patients with increased risk

  • GI upset
  • Black Box: Tendinopathy and rupture. Potentially permanent and disabling damage to tendons, muscles, joints, and nervous system including peripheral neuropathies.
  • C. difficile infection
  • CNS toxicity including fatigue, confusion, memory impairment, delirium, psychosis
  • Cardiac: QTc prolongation and risk for aortic aneurysm and dissection
  • Severe blood glucose disturbances, including hypoglycemic coma
  • Weakness exacerbation in myasthenia gravis
  • CYP1A2 inhibitor – increases plasma concentrations of CYP1A2 substrates (examples: Zyprexa, Clozaril, melatonin, Requip, mirtazapine, tizanidine, triamterene, theophylline)
  • Warfarin - Increased INR
  • Divalent & trivalent cations including Al, Ca, Fe, Mg (antacids, dairy products, iron supplements, some enteral feeds) - Decreased absorption
  • Cyclosporine - Increased levels of cyclosporine
  • Methadone - Lowered seizure threshold
  • Oral antidiabetic agents – increased risk of hyper and hypoglycemia, including hypoglycemic coma
  • QTc prolongation - Increased risk with other agents that prolong QTc

Antimicrobial class: Fluoroquinolone

Pregnancy category: C

Average serum half life: 4 hours

Biliary penetration: Therapeutic

CSF penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic