Daptomycin

Restricted
C difficile risk
Low
Oral Bioavailability
N/A

Dosing

Endocarditis or bloodstream infection 6-10 mg/kg IV daily

Non-bloodstream infections 4-6 mg/kg IV daily

Unknown for severe hepatic dysfunction

CrCl 0 - 30CrCl > 50Give dose q48hRegular dosing

Give dose after HD on dialysis days

8mg/kg IV q48h

General Information

Targeted therapy of resistant gram positive infections with MRSA (particularly when MIC≥2) and VRE including endovascular infection

Creatine kinase weekly

  • GI side effects common

  • Rash

  • Phlebitis

  • Increased INR

  • Myopathy including rhabdomyolysis

Statins and fibrates - Increased myopathy. Monitor creatine kinase or hold while on daptomycin therapy.

Higher doses used for endovascular infection.

Required Infectious Disease Consult.

Inactivated by pulmonary surfactant and therefore insufficient for pulmonary infection.

Antimicrobial class: Cyclic Lipopeptide.

Pregnancy category: B

Average serum half life: 9 hours

CSF penetration: Poor

Lung penetration: Poor

Urine penetration: Therapeutic

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