Daptomycin - Renal Dosing

In the setting of rapidly improving or worsening renal function, calculations of CrCl are inaccurate. Dosing should be based on estimated renal function instead.

If improving renal function, actual CrCl is likely higher than calculated CrCl.

If worsening renal function, actual CrCl is likely lower than calculated CrCl.

CrCl 0 - 30

Give dose q48h

CrCl > 50

Regular dosing

Give dose after HD on dialysis days

8mg/kg IV q48h

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