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Antimicrobials
Trimethoprim-Sulfamethoxazole

Trimethoprim-Sulfamethoxazole

Low
Excellent

Dosing

General Information

  •  Urinary tract infections
  •  Susceptible MRSA infections
  •  Stenotrophomonas infections
  •  Pneumocystis jirovecii pneumonia (Treatment or prophylaxis)

Monitor SCr, Sodium and Potassium, particularly in patients at increased risk of renal failure.

  •  Gastrointestinal upset common
  •  Bone marrow suppression
  •  Hyperkalemia
  •  Renal failure
  •  Hepatitis
  •  Aseptic meningitis
  •  Stevens Johnson syndrome/toxic epidermal necrolysis
  •  Other rashes

Increases INR with warfarin

ACEi /ARB - Increased serum potassium level

Increases: amantadine levels, phenytoin, rifampin

Decreases cyclosporine

Methotrexate - Marrow suppression

Antimicrobial class: Sulfonamide - Antifolate

Pregnancy category: C

Average serum half life: 10 hours

Biliary penetration: Moderate

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic